PROTINFO: secondary and tertiary protein structure prediction
نویسندگان
چکیده
منابع مشابه
PROTINFO: secondary and tertiary protein structure prediction
Information about the secondary and tertiary structure of a protein sequence can greatly assist biologists in the generation and testing of hypotheses, as well as design of experiments. The PROTINFO server enables users to submit a protein sequence and request a prediction of the three-dimensional (tertiary) structure based on comparative modeling, fold generation and de novo methods developed ...
متن کاملCoupled prediction of protein secondary and tertiary structure.
The strong coupling between secondary and tertiary structure formation in protein folding is neglected in most structure prediction methods. In this work we investigate the extent to which nonlocal interactions in predicted tertiary structures can be used to improve secondary structure prediction. The architecture of a neural network for secondary structure prediction that utilizes multiple seq...
متن کاملProtein secondary structure prediction.
The past year has seen a consolidation of protein secondary structure prediction methods. The advantages of prediction from an aligned family of proteins have been highlighted by several accurate predictions made 'blind', before any X-ray or NMR structure was known for the family. New techniques that apply machine learning and discriminant analysis show promise as alternatives to neural networks.
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Hepatitis B virus (HBV) infection is a universal health problem and may result into acute, fulminant, chronic hepatitis liver cirrhosis, or hepatocellular carcinoma. Sequence for protein X of HBV was retrieved from Uniprot database. ProtParam from ExPAsy server was used to investigate the physicochemical properties of the protein. Homology modeling was carried out using Phyre2 server, and refin...
متن کاملSecondary and tertiary protein structure I. Hierarchy of protein structure
Four levels in protein structural organization are commonly identified. Primary structure is a sequence of amino acids. Secondary structure is represented by regular local conformations of polypeptide chain, such as α-helix or β-strand. The combinations of two secondary structure elements are also sometimes referred to as secondary (or supersecondary) structure. The example is a β-hairpin forme...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2003
ISSN: 1362-4962
DOI: 10.1093/nar/gkg541